1st Gen Antipsychotics
| High | Haloperidol (Haldol) | EPS (acute dystonia, parkinsonism, akathisia, tardive dyskinesia) |
| Flupenthixol (Fluanxol) | ||
| Fluphenazine (Prolixin) | ↑↑↑ | |
| Medium | Perphenazine (Trilafon) | Side effect |
| Prochlorperazine | ||
| Pericyazine (Neuleptil) | spectrum from | |
| Zuclopenthixol (Clopixol) | high to low potency | |
| Loxapine (Loxapac) | ↓↓↓ | |
| Low | Methotrimeprazine (Nozinan) | anti-cholinergic / -adrenergic / -histamine |
| Chlorpromazine (Largactil) |
<u>Acute dystonia</u>: oculogyric/buccolingual/opisthotonic crisis, torticollis, laryngeal dystonia <u>Parkinsonism</u>: tremor, bradykinesia, rigidity, postural instability
<u>Anti-cholinergic</u>: dry mouth, constipation, ↑ temp urinary retention, blurred vision <u>Anti-adrenergic</u>: O-hypoTN, dizzy, reflex tachycardia <u>Anti-histaminergic</u>: sedation, weight gain
Antipsychotics - QT Prolongation
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Mood Stabilizers
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Antipsychotics - Seizure Risk
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Antidepressants - Sexual Dysfunction
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Antipsychotics - Weight Gain
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Antipsychotic Equivalents
| ANTIPSYCHOTICS | |
| TYPICAL Antipsychotics | Equivalent dose (mg) |
| Haloperidol (Haldol) | 2.5 |
| Flupenthixol (Fluanxol) | 2.5 |
| Fluphenazine (Prolixin) | 3 |
| Perphenazine (Trilafon) | 7.5 |
| Prochlorperazine | 15 |
| Pericyazine (Neuleptil) | 12.5 |
| Zuclopenthixol (Clopixol) | 12.5 |
| Loxapine (Loxapac) | 15 |
| Methotrimeprazine (Nozinan) | 75 |
| Chlorpromazine (Largactil) | 150 |
| ATYPICAL Antipsychotics | Equivalent dose (mg) |
| Risperidone (Risperdal) | 1.5 |
| Paliperidone (Invega) | 2 |
| Olanzapine (Zyprexa) | 5 |
| Ziprasidone (Zeldox) | 60 |
| Clozapine (Clozaril) | 100 |
| Quetiapine (Seroquel) | 75 |
| Aripiprazole (Abilify) | 7.5 |
| Brexpiprazole (Rexulti) | - |
| Lurasidone (Latuda) | 20 |
| Asenapine (Saphris) | 5 |
Doses in mg, equivalent to olanzapine 5 mg.
References (comment on the "Equivalency" header cell U4 in the sheet):
Benzodiazepines
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Stimulants (ADHD)
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